Quick answer
Вку́сно!
vkúsno — one word, and it will make your host’s evening
The options
The second helping
Refusing food once is read as politeness, not as a no. If you really are full, say Спаси́бо, я нае́лся with a smile — and expect to be offered again anyway.
What you hear back
Typical mistakes
Э́то есть вку́сно.
Э́то вку́сно.
No “is” in the present tense.
Вку́сный! — about the meal in general
Вку́сно!
The neuter short form вку́сно works as “it is tasty”; вку́сный needs a masculine noun.
Check yourself
Your host asks how the food is. What do you say?